For trace metal analysis, sample and standard preparation are required.

In a sample, trace metal analysis finds and quantifies very minute levels of metals including heavy metals. Although some trace metals are necessary for our health, many metals are poisonous and have detrimental consequences for human, animal, and plant health, as well as the environment. Trace metal analysis is used in quality control in the pharmaceutical, chemical, and petrochemical sectors to identify and measure metal contamination in products such as pharmaceuticals, fertilisers, cosmetics, packaging, medical devices, lubricants, and catalysts.

 Atomic Absorption Spectroscopy (AAS), Listeria Analysis Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES), and Inductive Spectroscopycoupled plasma mass spectrometry are all common analytical procedures for trace metal measurement (ICP-MS). 

The Value of Precision Weighing

ICP analysis of trace metals is a very delicate method. As a result, it’s critical that samples, reference standards,

and calibration standards are

carefully weighed, dosed, and diluted. With pipetting glassware and volumetric glassware, such as Erlenmeyer flasks, there are always errors inherent in the volumetric production of solutions and dilution series. The precision of gravimetric production of solutions and dilutions is substantially higher.

Developing Reference Standards for Trace Metal Analysis

Developing Reference Standards for Trace Metal Analysis

The development of reference standards with specific concentrations of each

metal potentially present is required for

the analysis of trace metals utilising spectroscopic techniques.  Automate chores that are tiresome and repetitive: Using gravimetric automated liquid dispensing with METTLER TOLEDO’s XPR Automatic Balance, this video shows how to prepare samples and reference standards for trace metal analysis quickly, efficiently, and safely. Benefit from sample volume reductions of up to 30%, automatic calculations and precise concentrations.

Trace Metal Analysis Workflow Example

Below is a general summary of the trace metal analysis workflow. The specifics of individual procedures depend on

the metallic element being examined, the sample matrix, and the analysis method chosen. It is critical to refer to the relevant standard techniques for precise specifics.

Almost every analytical procedure necessitates the creation of a set of calibration reference standard solutions with variable concentrations. The reference standards used to make the calibration standard solutions must

be extremely pure and free of elemental contaminants, as this may affect the trace metal measurement of the sample.

Trace Metal Analysis that Saves Money

The most time-consuming aspect of any laboratory analysis is accurate sample or standard preparation. When concentrations are as low as 0.001 g/g, as

they are with standard solutions for Inductively Coupled

Plasma (ICP) analysis, it becomes critical. Automated gravimetric dispensing saves time and reduces the number of standards and solvents used. By removing errors from equations, recording,

Analysis of trace metals

ICP–MS (inductively coupled plasma mass spectrometry)

the most recent, fastest, and most reliable technique is frequently used for trace metal analysis, which involves the detection of metals or their compounds in very low quantities. Many trace metals are nutrients that occur naturally in meals; others may appear as pollutants. Some can be harmful in high enough concentrations. As a service, we provide trace metal analysis in food, drink, raw materials, and additives.

 Rapid and accurate metals analysis is critical for assuring regulatory compliance, demonstrating due diligence, and fixing issues that arise. We use cutting-edge ICP-MS technology and our experience to produce accurate results quickly.

Metal and trace element testing services are available.

Metal speciation analysis Separation and speciation of elements in a pharmaceutical product enable more detailed risk assessments and analyses of both the benefits and hazards offered to test in the environmental testing laboratory in the USA

by constituents within a specific sample. As increasing research shows that free elements and diverse bound forms differ significantly in toxicity, element speciation will become even more critical

to ensure product safety and efficacy. The professionals use cutting-edge ICP-MS technology and methods to analyse metal species at ultra-trace levels, such as lead.

by combining ICP-MS with chromatography (LC, GC, Ion chromatography, etc.). Element’s complete elemental speciation solutions benefit pharmaceuticals, biologics, food, agricultural products, nutritional supplements and nutraceuticals, consumer goods, and other applications and industries.

The Benefits of Element’s

multi-analyte assays and processes for heavy metals

(e.g., mercury, cadmium, arsenic, and lead) are available through Element’s comprehensive trace

metal testing and analysis services, as well as entire

trace metals and elemental analysis quality control programmes. You can monitor elemental pollutants and heavy metals in pharmaceuticals, biologics, medical devices, raw materials, nutritional supplements, and more with

Element trace metal testing. To learn more about our trace metals testing and analysis services or to speak with one of our experts, contact us now.

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