There are not a few natural compounds that can have effects on brain health. After all, the brain is the most active tissue in the body.
One of nature’s most interesting compounds is flavonoids, a class of compounds called “nature’s biological response modifiers.” These compounds are primarily responsible for the colors found in many fruits, flowers, and other plants. They are essential for plant health and appear to be essential for human health as well.
More than 8,000 flavonoids have been identified. And while they share many essential functions such as increasing antioxidant mechanisms, combating aging and cell degeneration, and exerting beneficial effects on the cardiovascular system, there are subtle differences in how the different flavonoids function in the human body.
What is fisetin?
fisetin supplement is one of the most researched flavonoids. 1 Technically speaking, fisetin is a flavonol molecule similar to those found in dark chocolate and cocoa. Also, it is found in small amounts in special fruits and vegetables.
Strawberries have by far the highest content of this compound, followed by apples. The amount of fisetin in strawberries is approximately 5 times greater than that found in apples and generally more than 30 times greater than that found in mangoes, kiwis, grapes, tomatoes, onions, cucumbers, and various fruits dry.
However, the amount of fisetin in these foods is insufficient to provide the amount found in dietary supplements. The estimated daily intake of fisetin in Japan is 0.4 mg per day. The recommended daily dose of fisetin as a dietary supplement is 100 mg per day.
Health benefits of fisetin?
Like other sources of flavonoids such as quercetin, resveratrol, and grape seed extract, fisetin offers a wide variety of beneficial effects. This article will focus on the unique effects of fisetin on brain health, cognition, and memory.
- Activates antioxidant mechanisms to protect brain cells from damage.
- Increases glutathione content in brain cells to further protect the brain and also promote detoxification and better cellular energy.
- Supports the growth of new brain cells.
- It stimulates improved brain circuits and signaling pathways associated with long-term memory function.
Much of the research on fisetin in brain health has been conducted at the prestigious Salk Institute for Biological Studies, in San Diego, and has focused on fisetin as a “nootropic” and “neurotrophic” factor. The term “nootropic” is used to describe a substance that can improve memory and brain function. Other natural compounds that have this effect include lion’s mane extract, PQQ with CoQ10, resveratrol, and curcumin.
What distinguishes fisetin is its action as a neurotrophic factor. This type of compound favors the survival, differentiation, and functional maintenance of brain cells. In other words, fisetin is a little different in that, in addition to helping brain cells function better, as a neurotrophic factor it plays a role in improving what’s known as “brain plasticity.”
Brain plasticity refers to the brain’s ability to respond in order to develop new or restored brain circuits. Brain plasticity is important for brain functions like learning and memory to work properly. Thus, by acting as a neurotrophic to enhance brain plasticity, fisetin may promote the formation of enhanced brain circuits and signaling pathways associated with long-term memory function.
Of all the flavonoids tested in full-spectrum animal models for age-related brain changes, only fisetin and a related minor flavonol were shown to be effective. two
How does fisetin work?
Fisetin can cross the blood-brain barrier to act through a very complex set of mechanisms to produce its effects as a nootropic and neurotrophic agent. And, again, fisetin’s actions are a bit different from other compounds, although it shares many actions with other flavonoids. For example, fisetin shares some antiaging properties with resveratrol. It is also an effective senolytic agent, meaning it helps the body and brain get rid of old cells with a “pruning” effect that allows healthier cells to proliferate or replace old cells. Fisetin has approximately twice the ability of quercetin to achieve this effect.
Like other flavonoids, fisetin also increases the production of glutathione, the key antioxidant and detoxifying agent in our cells. Increasing glutathione levels in the brain produce all kinds of benefits, as the brain is better able to protect itself against damage and has higher levels of cellular energy. two
One of the essential actions of fisetin is to activate what is known as the ERK pathway. 3 ERK is an acronym in English that stands for “extracellular signal-regulated kinases”. Extracellular means “outside the cell” and kinases refer to a class of enzymes. ERKs are produced when something outside the cell sends a signal inside the cell to activate kinase enzymes.
nmn 500 mg helps brain cells start making proteins that are critical to their own structure and function, especially at the communication junctions known as synapses between cells. It also reduces various markers of inflammation within synaptic connections.
By activating the ERK pathway, fisetin can improve the structure and function of brain cells. This results in an improvement in cognition and memory. This effect has been repeatedly demonstrated in preclinical studies. 23
What is the recommended dose of fisetin?
There are only two human studies with fisetin and both used a daily dose of 100 mg. 5,6 This dose was calculated from a substantial amount of animal data showing efficacy and safety that allow the human dose to be calculated based on US Food and Drug Administration (FDA) guidelines.
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